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diagnosis differential rheumatology vasculitis allergy comparison hypersensitivity potassium reactions sle champs clinicopathology cryoglobulinemia cryoglobulins druginduced erythematosus gammopathy glomerular hematology high
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... differential #diagnosis #algorithm
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... , type 1 (50%-80% ... S - Systemic Lupus ... Hypocomplementemia #Low ... #Complement #CHAMPS
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Allergen-specific lgE causes ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... #classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Complement activation ... Post-streptococcal glomerulonephritis ... , and systemic lupus ... #Classification ... Diagnosis #Reactions #Table
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... factor level • Low ... serum C4 complement ... (e.g. systemic lupus ... #classification
Hypokalemia - Differential Diagnosis Poor Intake - Starvation - Anorexia GI Losses - Vomiting / NG
and 2, but not type ... Differential #Diagnosis #Low ... #Potassium #Table ... #Classification ... #Causes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... complement - Rare ... 60-80% - Low ... complement - 50 ... sle #comparison #table
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... Skin Disease Classification ... Kikuchi disease • Type-I ... , lymphopenia, low
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
in monitoring low-level ... or alternative complement ... infections are common causes ... cryoglobulinemias (types ... workup #diagnosis #glomerulonephritis
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