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diagnosis rheumatology allergy differential hypersensitivity lupus reactions vasculitis clinicopathology compared cryoglobulinemia cryoglobulins dermatology druginduced endocarditis erythemas erythematosus infective laboratory management
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes ... Anaphylaxis, Hay fever ... glomerulonephritis, Systemic ... #classification ... #comparison
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... , seasonal hay fever ... Complement activation ... #Classification ... Diagnosis #Reactions #Table
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... #classification
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... Discontinuation of causal ... months to years) Systemic ... 80% - Low complement ... #comparison #table
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... weight loss, and fever ... anti-Smith Ab, low complements ... Skin Disease Classification ... Kikuchi disease • Type-I
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
conditions: Autoimmune (SLE ... -, Systemic embolism ... in up to 30% of cases ... #Endocarditis #comparison ... Marantic #diagnosis #table
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
form of delayed-type ... (cutaneous or systemic ... multiforme • Acute systemic ... PrathitKulkarni #Erythemas #comparison ... #table #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Vasculitis: • Fevers ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
6/02/2022 UPDATE: This assay is designed to detect non-variola orthopoxviruses, including monkeypox virus. It is not
2022-lab-advisory-CLARIFICATION-CDC_Publishes_Non-variola_Orthopoxvirus_PCR_Testing_Procedure ... should use this algorithm ... smallpox-diagnostic-algorithm-poster ... The type of specimen ... See table below
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