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diagnosis rheumatology differential nephrology glomerulonephritis medium nephrotic small testing workup acute aki anca cryoglobulinemia cryoglobulins disease erythematosus gammopathy im initial
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Small #Medium #Large ... #Vessel #Size #Classification ... #Differential #Algorithm ... #Ddxof
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
involvement by large ... Large vessel vasculitis ... affects large arteries ... Anti-GBM = anti–glomerular ... #Classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... - Skin, glomeruli ... , arthritis LARGE ... against MPO • Complement ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Kidney Injury - Classification ... - Small vessel vasculitis ... - TTP/HUS • Glomerular ... tubular necrosis (causes ... Kidney #Injury #Classification
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... infections are common causes ... of glomerular disease ... for ANCA-related vasculitis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... • Vasculitis ... diagnosis #types #classification
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... #glomerular #disease
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... discrepancies LARGE ... • Kidneys: Non-glomerular ... tract, and often causes ... chorioretinitis, CNS large
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... ANCA-associated vasculitis ... the small and large ... RNP antibodies, Complement
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