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differential causes laboratory acid acidosis adrenal algorithm alkalosis base calcium cell elevated gout hematology hyperparathyroidism hypertension hyperuricemia hypocalcemia indications insufficiency
Hypocalcemia Laboratory Evaluation Serum levels of PTH, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D can help differentiate between
Evaluation Serum ... differentiate between disorders ... deficiency - Chronic ... Hyperparathyroidism #Diagnosis ... #Endocrinology
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 Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
Hypercalcemia Evaluation ... BrighamChiefs #Hypercalcemia ... #workup #differential ... #diagnosis #endocrinology ... #workup
Causes of Hypercalcemia Parathyroid hormone–dependent Primary hyperparathyroidism Familial hypocalciuric hypercalcemia Lithium-associated Tertiary hyperparathyroidism Genetic disorders (e.g., multiple endocrine neoplasia type 1 or
Causes of Hypercalcemia ... hyperparathyroidism Genetic disorders ... failure, acute or chronic ... #Differential #Diagnosis ... #Endocrinology
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 Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... Vitamin D metabolic disorders ... Pheochromocytoma Chronic ... #Causes #endocrinology ... #diagnosis #differential
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
- Differential Diagnosis ... Lymphoproliferative Disorders ... (AML) • Chronic ... Sarcoidosis • Hypercalcemia ... #Algorithm #endocrinology
Approach to Acid Base Disorders - Evaluation and Differential Diagnosis 1) Start with the Anion Gap (AG). 2)
- Evaluation and ... Differential Diagnosis ... chronicity (acute, chronic ... , or acute on chronic ... #Evaluation #workup
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Hypertension - Workup ... and Differential Diagnosis ... Approach (when evaluation ... Vasculitis • Endocrinologic ... Hyperthyroidism, Hypercalcemia
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
secretion; in chronic ... Insufficiency #Evaluation ... #laboratory #diagnosis ... #testing #endocrinology ... #workup
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... Biopsy: Solitary disorder ... CRAB - no anemia, hypercalcemia ... Evaluation? ... #Workup #Hematology
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