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hematology algorithm macrocytic oncology aafp chronic cll differential folate folicacid gap homocysteine leukemia lymphocytic macrocytosis microcytic mma plasmacytoma protein proteingap
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... • Neutropenia, anemia ... increase in gamma globulins ... ’s lymphoma or acute ... #workup #oncology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the evaluation ... RBC = red blood cell ... by ordering a peripheral ... of the initial work-up ... #Diagnosis #Macrocytosis
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... immature RBCs) in peripheral ... High in acute blood ... #Workup #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... myeloma • Plasma cell ... anemia • Other ... #differential #diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
ridging around the periphery ... Diagnosis? ... • No CRAB - no anemia ... Evaluation? ... #Workup #Hematology
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