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hematology differential oncology algorithm causes macrocytic pathophysiology aafp apl auer auerrods b12 bandemia blood bloodsmear cancer cbc cell chronic clinical
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... blasts in the peripheral ... ALL (Acute Lymphoblastic ... - infiltrates (anemia ... Hematology #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cytometry • Peripheral ... • Neutropenia, anemia ... ’s lymphoma or acute ... leukemia #CLL ... #diagnosis #workup
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the evaluation ... by ordering a peripheral ... of the initial work-up ... #Diagnosis #Macrocytosis ... Homocysteine #Algorithm #Workup
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... immature RBCs) in peripheral ... High in acute blood ... #Algorithm #Diagnosis ... #Workup #Hematology
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... She was diagnosed ... with acute promyelocytic ... and started on all-trans ... treatment, her peripheral
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 Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... plateletcount), peripheral ... changes), high MCV anemia ... - Bone marrow evaluation
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
tongue), abd pain, diarrhea ... total body stores Evaluation ... findings, HSM, LN, peripheral ... consider other diagnosis ... e.g. leukemia
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
approximately 5-10% of peripheral ... Differential Diagnosis ... Tissue damage • Leukemia ... count on initial evaluation ... #differential #diagnosis
Anemia of Hospitalization - Pathophysiology Why does the Hgb/Hct drop in the first two days during hospitalization? Interestingly,
phlebotomy/ blood work ... during clinical evaluations ... blood loss or acute ... of unnecessary diagnostic ... #differential #diagnosis
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