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IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis - Induction, Consolidation and Maintenance Therapy

Table 2. Antifungal Treatment Recommendations
for Cryptococcal ... Recommendations for Cryptococcal ... Recommendations for Cryptococcal ... #management #meningitis ... #cryptococcus
Papilledema on Fundoscopy Ocular Examination

31 year old male with cryptococcal meningitis. CD4 count 44, 1 year
old male with cryptococcal ... meningitis. ... year without ART treatment ... #Papilledema #cryptococcus
Important Fungal Stains
Mycology Lab:
 • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... meningitis; some ... mucopolysaccharide capsule of Cryptococcus ... fungus #comparison #table
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Human Immunodeficiency Virus Infected Individuals
Induction therapy:
 • AmBd (0.7–1.0
IDSA Treatment Recommendations ... for Cryptococcal ... week) >1 year #Cryptococcal ... #management #meningitis ... #cryptococcus #
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis in Transplant Recipients
Induction therapy:
 • liposomal AmB (3–4 mg/kg per
IDSA Treatment Recommendations ... for Cryptococcal ... year B-III #Cryptococcal ... #management #meningitis ... #cryptococcus #
Initiation of ART in HIV patients with Opportunistic Infections
 • Pulmonary TB and CD4 cell count
regardless of CD4 • Cryptococcal ... Meningitis • ... of starting OI treatment
Differential Diagnosis for Concurrent Brain and Lung Infections
 • Bacteria: Strep anginosus, Staph aureus, Klebsiella pneumoniae
Diagnosis for Concurrent ... Brain and Lung ... Mucormycosis, Cryptococcus ... @ID_fellows #Brain ... Lung #Infections #Concurrent
Concurrent Brain and Lung Lesions
 • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... Lung #Infections #Concurrent
Concurrent Brain and Lung Lesions
 • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... Mucormycosis, Cryptococcus ... febrilepodcast #Brain ... Lung #Infections #Concurrent
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Fluconazole CRYPTOCOCCUS ... level, presence of cryptococcal ... CSF and serum Cryptococcal ... • Sinusitis • Brain ... infection (~40%) • Meningitis