8 results
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... 40 ml/min A - Anemia ... Look for gamma gap ... MGUS #diagnosis #hematology ... #oncology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... changes), high MCV anemia ... disease), HBsAg ... - Bone marrow evaluation ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... first step in evaluation ... Sarcoidosis) • Liver ... gastric tumors • Hematology ... differential #diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... (-) hemolytic anemia ... Pseudohyponatremia • ↓anion gap ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... deficiency • Liver ... - APLS • Acute ... vasculitis - GPA ... Differential #Diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Neutropenia, anemia ... ’s lymphoma or acute ... Leukemia #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
common - GI tract, liver ... • No CRAB - no anemia ... #Plasmacytoma #Oncology ... #Diagnosis #Workup ... #Hematology