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diagnosis hepatology differential algorithm hepatitis management acute aih chemistry chronic dili druginduced failure gap gastroenterology globulin interpretation lfts protein proteingap
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... disease, liver ... Injury (DILI) ... #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Liver Injury: ... • Autoimmune: ... Autoimmune hepatitis ... hepatitis: < 1 • Cirrhosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... disease, Hepatic ... dechallenge • Acute ... steatosis • Autoimmune ... #Algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALF): • Liver ... of cholestatic disease ... disease: > 2 ... hepatitis: < 1 • Cirrhosis ... #differential #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... from subclinical disease ... to acute liver ... injury, though ... regarding need for treatment
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... Sarcoidosis) • Liver ... disease: Cirrhosis ... , ETOH, autoimmune
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