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hematology differential oncology lymphocytic abdominal bandemia causes cbc diarrhea gastroenterology globulin hemeonc management mds myelodysplasia myelodysplastic neutrophil pain pathophysiology protein
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... activity • ↓ LAP ... Headaches, bone pain, fever ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Lymphadenopathy • Fevers ... weeks without infection ... #Leukemia #diagnosis ... #workup #oncology
Chronic Diarrhea - Workup Osmotic: • Consider food diary and trial avoiding certain foods or meds, Consider
Chronic Diarrhea ... - Workup Osmotic ... certain foods or meds ... Stool osmotic gap ... #testing #evaluation
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... ) B symptoms → fevers ... Complications: 1) Infection ... uw_IMresidency #CLL
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
have had prior evaluations ... Red Flags: • Fever ... thrombus • Splenic infarction ... • Lymphoma/Leukemia ... bowel syndrome • Celiac
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Differential Diagnosis ... Tissue damage • Leukemia ... tachycardia or fever ... count on initial evaluation ... neutrophil #WBC #CBC #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... leukemia • Solitary ... Include: • Viral infections ... #differential #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... Myelogenous Leukemia ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis
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