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differential causes cobalamin iron gastroenterology hematology vitamin disorders gastrointestinal ileal low management mds myelodysplasia myelodysplastic oncology pancytopenia pouch surgery syndromes
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Deficiency - Cobalamin ... Intestine: SIBO, Celiac ... disease, IBD, Lymphoma ... Stomach: Pernicious anemia ... #differential #diagnosis
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Loss (without anaemia ... Bleeding, Edema, Celiac ... #differential #diagnosis ... #causes #nutrition
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... with anemia, diagnose ... tests Test for celiac ... disease with serology ... #Evaluation #workup
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Drugs, H pylori, Celiac ... : IBD, Chronic disease ... #differential #diagnosis ... #anemia #nutrition
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... : • GATA2 deficiency ... • Fanconi’s anemia ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... related to IBD, celiac ... disease, other ... total body stores Evaluation ... #nutrition
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
of Low Vitamin B12 ... Levels Low vitamin B12 ... Autoimmune - Pernicious anaemia ... , coeliac disease ... #differential #diagnosis
Ileal Pouch Disorders - Differential Diagnosis • Surgical/Mechanical: Anastomotic leak, Pelvic sepsis, Sinus, Fistula, Strictures, Efferent
- Differential Diagnosis ... Systemic/Metabolic: Anemia ... Bone loss, Vit D/B12 ... deficiency, Renal ... stone, Celiac disease
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myeloproliferative Disease ... Platelet Disorders • Nutritional ... : vitamin B12 or ... folic acid deficiency ... Myelodysplastic #Syndromes #diagnosis
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