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diagnosis differential hematology algorithm anemia cobalamin mcv acidosis alkaline alp approach diabetes dm2 elevation endocrinology falls fe geriatrics hepatology high
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Diagnosis Algorithm Low ... (>100 fL) • B12 ... #Anemia #MCV #Classification ... Diagnosis #Algorithm #Causes
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... , coeliac disease ... #VitaminB12 #deficiency
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Approach - MCV) Low ... kidney disease, ... Megaloblastic: Vitamin B12 ... Alcohol use, Liver disease ... differential #diagnosis #causes
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... Pregnancy, Lactation, Low ... kidney disease, ... of absorption): Celiac ... disease, Bypass
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... • B12/Folate ... Disease • Marrow ... Non-lmmune #Anemia #Classification ... Diagnosis #Algorithm #Causes
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... related to IBD, celiac ... disease, other ... total body stores Evaluation
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
agent • Does not cause ... hypoglycemia • Low ... Contraindications: • Chronic ... titration • B12 ... deficiency (consider
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
thigh bones -> chronic ... Malnutrition • Wilson's disease ... Pernicious anemia/B12 ... deficiency • ... Phosphatase: • Other causes
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
presentations and disease ... malignancy, or thiamine deficiency ... LV failure - Low ... effect - Thiamine deficiency ... #typea #typeb #classification
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... Myeloproliferative Disease ... Nutritional: vitamin B12 ... or folic acid deficiency ... treatments • Copper deficiency
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