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diagnosis blood hematology product reactions abdominal algorithm b12 chronic cobalamin gastroenterology hemophagocytic lymphohistiocytosis nutrition pain pediatrics rheumatology summary transfusion transfusions
Causes of Pediatric Diarrhea - Differential Diagnosis Algorithm Infectious: • Viral • Bacterial • Parasitic Malabsorption: • Lactase
Causes of Pediatric ... Diarrhea - Differential ... Cystic Fibrosis • Celiac ... Disease • Primary ... #Peds #Pediatrics
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... Cellular immune deficiency ... Drugs, Unknown cause ... inhibitors under evaluation ... Lymphohistiocytosis #diagnosis #management
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
- Differential ... have had prior evaluations ... Red Flags: • Fever ... • Vomiting, diarrhea ... #Differential #
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... tongue), abd pain, diarrhea ... related to IBD, celiac ... disease, other ... #diagnosis #management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... recipients w/ IgA deficiency ... donors (due to anti-HLA ... cutaneous eruptions, diarrhea ... Transfusion #diagnosis #management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
S/sx: Fever, flank ... recipients w/ IgA deficiency ... donors (due to anti-HLA ... cutaneous eruptions, diarrhea ... Transfusions #diagnosis #management
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