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hematology differential testing algorithm arthritis bandemia causes chronic cll disorders gap globulin hemolytic laboratory leukemia lymphocytic neutrophil oncology pathophysiology platelet
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... ): SS, SC, SE, Sβ ... defects, Glutathione metabolism ... #Algorithm #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... - Bone marrow evaluation
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Differential Diagnosis ... ingestions • Metabolic ... • Autoimmune diseases ... count on initial evaluation ... #CBC #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... the presence of anemia ... Complete blood count (CBC ... protein) to exclude metabolic ... #Rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... hallmark for the disease ... result in severe anemia ... from ischemia WBC ... #Workup #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... autoimmune hepatitis, PBC ... Thalassemia, Sickle cell anemia ... #differential #diagnosis
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