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diagnosis management lupus erythematosus systemic ana antibodies antinuclear autoantibodies differential druginduced hivaids idsa infections medications mycobacterium opportunistic prevention syndrome activation
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
response to the drug ... #treatment #medications ... #table #pharmacotherapy ... #hematology #warfarin ... #dosing
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
RA Anti-dsDNA - SLE ... Anti-histone - Drug-induced ... SLE Anti-Jo-1 - ... #diagnosis #table ... #rheumatology #
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... also be measured using ... (60-70%) & drug-induced ... erythematosus #diagnosis #rheumatology ... #table #ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence ... (MCTD), Drug-induced ... Idiopathic Arthritis, Drug-Induced ... Biliary Cirrhosis, Drug-Induced ... ANA #patterns #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... life-threatening • Treatment ... Evolution: Chronic disease ... #comparison #table ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... extremities Drug ... • Antihistone: Drug ... Erythematosus #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease, ... immune deficiency, Drugs ... #summary #rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
SLE High risk ... for 1 year of treatment ... #DrugInduced #SLE ... #pharmacology # ... differential #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... ) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment ... lubricants • Pharmacologic ... Sjogrens #Syndrome #Rheumatology
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