1183 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Inherited (AR) hypokalemic ... with thiazide diuretic ... Surreptitious diuretic ... nephrology #management #pathophysiology ... #Hypokalemia
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... syndrome • Triggers: Diuretics ... Lysis Syndrome: • Pathophysiology ... hydration - Hyperkalemia
Treatment of hyperkalemia via kaliuresis 
step 1 = volume resuscitation if hypovolemic
step 2 = consider fludrocortisone
step
Treatment of hyperkalemia ... fludrocortisone step 3 = diuretic ... determine response to diuretic ... #hyperkalemia ... #diuresis #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Dermatomyositis) AKI - Pathophysiology ... Loop diuretics for ... Dialysis for severe hyperkalemia
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
lost via osmotic diuresis ... To prevent hypokalemia ... DiabeticKetoacidosis #DKA #pathophysiology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... ß-Adrenergic agonists, Hypokalemic ... congenital), Thyrotoxic hypokalemic ... , Osmotic diuresis ... or induced) #Hypokalemia
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... of Action Diuretics ... Adenosine #Nephron #Pathophysiology ... #Diuretics #Sites
Cardiac Arrest - H's and T's

HYPOVOLEMIA 
HYPOXEMIA 
HYPERKALEMIA 
HYPOKALEMIA 
H+ EXCESS
HYPOTHERMIA 

TENSION PNEUMOTHORAX 
TAMPONADE - CARDIAC
H's and T's HYPOVOLEMIA ... HYPOXEMIA HYPERKALEMIA ... HYPOKALEMIA
“H’s & T’s“ - The reversible causes of Cardiac Arrest 
Hypovolemia, Hypoxia/Hypoxemia, Hydrogen Ion Excess (Acidosis),
Cardiac Arrest Hypovolemia ... Excess (Acidosis), Hypokalemia ... /Hyperkalemia, Hypothermia
Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... book-info #Nephron #Diuretics ... Location #Nephrology #Pathophysiology