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rheumatology management hematology activation antimda5 antimda5dm antinxp2 antinxp2dm erythematosus hemophagocytic hlh lupus lymphohistiocytosis macrophage mas sle systemic treatment
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
dorsal part of the MCP ... auricular papules Clinical ... anti-NXP2 Abs Lung ... #rheumatology #dermatology ... #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... : HLH signs and ... Ferritin >500 ng/mL ... management #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... Fever is the main clinical ... rash) • Heart, lung ... 5000 to 10,000 ng/mL ... #Diagnosis #Management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... dorsal part of the MCP ... auricular papules Clinical ... Non-small-cell lung ... #rheumatology #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... Still disease, dermatomyositis ... Clinical Features ... La, anti-Jo-1, SCL
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