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management hematology neurology differential oncology sclerosis algorithm als chronic cll disorders eosinophil eosinophilia lateral leukemia leukostasis lymphocytic lysis mds ms
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... glucocorticoid treatment ... organ-specific signs ... or symptoms (eg ... #Differential #diagnosis
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Amyotrophic Lateral ... examination finding of amyotrophy ... - Causes progressive ... fasciculations Common Symptoms ... column Treatment
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
neuritis • Partial myelitis ... • Or brainstem syndromes ... Signs and symptoms ... Multiple Sclerosis Treatment ... management #neurology #treatment
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Bilateral signs ... and/or symptoms ... Pleocytosis > 100 cells ... • Infectious causes ... Treatment: •
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Dehydration • Symptoms ... WBC >100k, + lab signs ... Lysis of tumor cells ... #TLS #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... skin that are caused ... Workup: • Complete ... #diagnosis #hematology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... tissue: Epithelioid cells ... at the time of diagnosis ... anterior/posterior MSK ... #Management #Signs
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy Presentation:
Bell's Palsy - Diagnosis ... ophthalmoplegia), systemic signs ... Imaging (if atypical symptoms ... CNS inflammatory cause ... #Management #Treatment
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... microglobulin Treatment ... • Richter’s Syndrome ... #workup #oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... Hypocomplementemia • Can cause ... neuropathy, transverse myelitis ... phenomenon (16%) MSK ... Adenocarcinoma Treatment
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