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hematology anemia disease hemolytic management workup chronic cold differential erythematosus leukemia lupus lymphocytic oncology polychondritis relapsing signs syndrome systemic testing
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoid malignancy (CLL ... Viral Infection Clinical ... significance (MGUS), CLL ... Hemoglobinuria (PCH ... hemolytic #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... Consider sickle cell ... genotypes): SS, SC, SE ... Agglutination - Cold agglutinins ... aHUS, mechanical cardiac
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Orange or Hep C Clinical ... with no early symptoms ... Diagnosis: • ... Transform to DLBCL, PML
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
thrombosis, VTE) • Cardiac ... syndrome (Clinical ... Oral aphthae : SLE ... • Arthritis: SLE ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... Cytopenias • Cardiac ... Induced Lupus: • Symptoms ... #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Males • Affects all ... cases such as: • SLE ... vessel aneurysms • Cardiac ... Sarcoidosis • Behcet ... Polychondritis #rheumatology
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