121 results
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... agent • Does not cause ... not initiate if eGFR ... not continue if eGFR ... causing lactic acidosis
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... Risk of Lactic Acidosis ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... annually if on metformin
Anion Gap Metabolic Acidosis
 • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar
 • Alcoholic Ketoacidosis ± Hyperglycemia
Gap Metabolic Acidosis ... Type B lactic acidosis ... Drugs ( Albuterol, Metformin ... Cirrhosis • Uremic Acidosis ... AnionGap #Metabolic #Acidosis
Lactic Acidosis Classification - Type A vs Type B
Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type A Lactic Acidosis ... Type B Lactic Acidosis ... Renal failure, Metformin ... Linezolid #Lactic #Acidosis
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Metformin Associated ... Lactic Acidosis ... Pathophysiology of MALA - Metformin ... symptoms of metabolic acidosis ... Kat_Watson #MALA #Metformin
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... T2D, CKD, & an eGFR ... per 1.73 m2 with metformin ... CKD #ADA #KDIGO #eGFR ... #Insulin #metformin
Kussmaul Breathing in Lactic Acidosis
Acute non-cardiopulmonary dyspnoea. 70 ys, DM, vomiting and URQ abdominal pain since
Breathing in Lactic Acidosis ... severe lactic acidosis ... regularly taken metformin ... for metabolic acidosis
Renal tubular acidosis (RTA): refers to a group of conditions all of which cause the same
Renal tubular acidosis ... conditions all of which cause ... result: a metabolic acidosis ... different types/causes
Cat Mudpiles - Causes of high anion-gap metabolic acidosis

#CATMUDPILES #AnionGap #Metabolic #Acidosis #Mnemonic #Diagnosis #MUDPILECATS
Cat Mudpiles - Causes ... anion-gap metabolic acidosis ... AnionGap #Metabolic #Acidosis