103 results
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... Renal Dose Adjustments ... Risk of Lactic Acidosis ... 45-60 Monitor eGFR ... #Renal #Dosing
Lactic Acidosis Classification - Type A vs Type B
Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type A Lactic Acidosis ... Type B Lactic Acidosis ... bowel (D-lactate), Renal ... failure, Metformin
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... annually if on metformin
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... not initiate if eGFR ... not continue if eGFR ... causing lactic acidosis ... EricsMedicalLectures/ #Metformin
Interpreting Kidney Biomarkers

↑ Creatinine: 
 • AKI, CKD
 • Medications that lead to nephroprotective ↓ in
nephroprotective ↓ in GFR ... Medications that ↓ renal ... hyperthyroidism ↓ eGFR ... Biomarkers #Kidney #renal
Renal Failure Prognosis - The eGFR and proteinuria offers a general prognosis as demonstrated in the
Renal Failure Prognosis ... - The eGFR and ... #CKD #EGFR #Proteinuria
Anion Gap Metabolic Acidosis
 • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar
 • Alcoholic Ketoacidosis ± Hyperglycemia
Gap Metabolic Acidosis ... Type B lactic acidosis ... Drugs ( Albuterol, Metformin ... Cirrhosis • Uremic Acidosis ... AnionGap #Metabolic #Acidosis
Renal Tubular Disorders

 • Distal Renal Tubular Acidosis (Type 1)
 • Proximal Renal Tubular Acidosis (Type
• Distal Renal ... Tubular Acidosis ... Tubular Acidosis ... Tubular Acidosis ... #Tubular #Acidosis
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Metformin Associated ... Lactic Acidosis ... Pathophysiology of MALA - Metformin ... symptoms of metabolic acidosis ... Kat_Watson #MALA #Metformin
Metformin: Biguanide
Metformin is the first-line medication for treatment of type 2 diabetes. It is very effective
Metformin: Biguanide ... Metformin is the ... attention to patients renal ... function since lactic acidosis ... /ambcarerx #Metformin