44 results
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... Risk of Lactic Acidosis ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... annually if on metformin
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... not initiate if eGFR ... not continue if eGFR ... causing lactic acidosis ... EricsMedicalLectures/ #Metformin
Anion Gap Metabolic Acidosis
 • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar
 • Alcoholic Ketoacidosis ± Hyperglycemia
Gap Metabolic Acidosis ... Type B lactic acidosis ... Drugs ( Albuterol, Metformin ... Cirrhosis • Uremic Acidosis ... AnionGap #Metabolic #Acidosis
Lactic Acidosis Classification - Type A vs Type B
Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type A Lactic Acidosis ... Type B Lactic Acidosis ... Renal failure, Metformin ... Linezolid #Lactic #Acidosis
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Metformin Associated ... Lactic Acidosis ... Pathophysiology of MALA - Metformin ... symptoms of metabolic acidosis ... Kat_Watson #MALA #Metformin
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... T2D, CKD, & an eGFR ... per 1.73 m2 with metformin ... CKD #ADA #KDIGO #eGFR ... #Insulin #metformin
Kussmaul Breathing in Lactic Acidosis
Acute non-cardiopulmonary dyspnoea. 70 ys, DM, vomiting and URQ abdominal pain since
Breathing in Lactic Acidosis ... severe lactic acidosis ... regularly taken metformin ... for metabolic acidosis
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
Medications Summary Table ... modifications Metformin ... #medications #table
Unmeasured Anions Associated with an Elevated Anion Gap and Metabolic Acidosis

#Unmeasured #Anions #Gap #Metabolic #Acidosis #Diagnosis
and Metabolic Acidosis ... Gap #Metabolic #Acidosis ... Diagnosis #Nephrology #Table