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diagnosis differential nephrology algorithm management cardiology pharmacology diabetes pathophysiology clinical medications renal rheumatology treatment table acute classification comparison dm2 dosing
The GFR Clock for Staging CKD Staging CKD is most frequently done by calculating the estimated glomerular
Staging CKD Staging ... CKD is most frequently ... function rate (eGFR ... calculating the eGFR ... to remember the eGFR
Metformin in Diabetic Kidney Disease Immediate release: • Initial 500 mg or 850 mg once daily •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... #CKD #pharmacology
Definitions of AKI, CKD, AKD Acute Kidney Injury (AKI): • Increase in SCr by 2 50% within
Definitions of AKI, CKD ... ): • GFR < 60 ... • AKI, OR • GFR ... • Decrease in GFR ... ): • GFR ≥ 60
Management of Diabetes Mellitus in Patients With CKD 1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... , & an eGFR ≥ 30 ... per 1.73 m2 with metformin ... ADA #KDIGO #eGFR ... #Insulin #metformin
Interpreting Kidney Biomarkers ↑ Creatinine: • AKI, CKD • Medications that lead to nephroprotective ↓ in
Creatinine: • AKI, CKD ... nephroprotective ↓ in GFR ... Cystatin C: • AKI, CKD ... hyperthyroidism ↓ eGFR
Patient factors influencing the selection Of glucose-lowering drugs Other than SGLT2i and metformin in T2D and
than SGLT2i and metformin ... in T2D and CKD. ... —4 inhibitor, eGFR ... , #KDIGO2020 #CKD ... Management in CKD
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or
Metformin Treatment ... /dc17-2231 #Metformin ... #CKD3 #CKD4 #Dosing
Metformin Current Renal Dose Adjustments due to Risk of Lactic Acidosis > 60 No adjustment 45-60
Metformin Current ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin
Renal Failure Prognosis - The eGFR and proteinuria offers a general prognosis as demonstrated in the
Prognosis - The eGFR ... #CKD #EGFR #Proteinuria
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... agent • Does not cause ... not initiate if eGFR ... not continue if eGFR ... EricsMedicalLectures/ #Metformin
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