63 results
Patient factors influencing the selection Of glucose-lowering drugs Other than SGLT2i and metformin in T2D and
than SGLT2i and metformin ... —4 inhibitor, eGFR ... sulfonylurea; T2D. type 2 diabetes ... type 2 diabetes; ... #Diabetes Management
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... #CKD #pharmacology
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... , & an eGFR ≥ 30 ... #Diabetes #CKD # ... ADA #KDIGO #eGFR ... #Insulin #metformin
The GFR Clock for Staging CKD

Staging CKD is most frequently done by calculating the estimated glomerular
Staging CKD Staging ... CKD is most frequently ... function rate (eGFR ... calculating the eGFR ... #EGFR #Staging
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or
Metformin Treatment ... Patients With Type 2 Diabetes ... 3A, 3B, or 4 Diabetes ... /dc17-2231 #Metformin ... #CKD3 #CKD4 #Dosing
Diabetes Type 2 Medication Management and Titration Algorithm
- First line therapy is metformin and comprehensive lifestyle
Diabetes Type 2 ... line therapy is metformin ... Established ASCVD or CKD ... established ASCVD or CKD ... #Diabetes #DM2
Summary of dosing recommendations in renal impairment of commonly used hypoglycaemic agents

#Diabetes #Diabetic #Medications #Pharmacology #Dosing
hypoglycaemic agents #Diabetes ... #Diabetic #Medications ... Renal #Impairment #CKD ... #Table #GFR #Hypoglycemics
Definitions of AKI, CKD, AKD
Acute Kidney Injury (AKI):
 • Increase in SCr by 2 50% within
Kidney Disease (CKD ... ): • GFR < 60 ... ): • GFR ≥ 60 ... /CKD • No structural ... damage #AKI #CKD
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin ... #Pharmacology #Diabetes
Interpreting Kidney Biomarkers

↑ Creatinine: 
 • AKI, CKD
 • Medications that lead to nephroprotective ↓ in
Creatinine: • AKI, CKD ... nephroprotective ↓ in GFR ... Cystatin C: • AKI, CKD ... hyperthyroidism ↓ eGFR