132 results
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... Kidney Disease ... maximum dose eGFR ... recommended dose eGFR ... #CKD #pharmacology
Patient factors influencing the selection Of glucose-lowering drugs Other than SGLT2i and metformin in T2D and
than SGLT2i and metformin ... in T2D and CKD. ... cardiovascular disease ... kidney disease, ... —4 inhibitor, eGFR
Definitions of AKI, CKD, AKD
Acute Kidney Injury (AKI):
 • Increase in SCr by 2 50% within
Chronic Kidney Disease ... (CKD): • GFR ... Acute Kidney Diseases ... months No Kidney Disease ... (NKD): • GFR
The GFR Clock for Staging CKD

Staging CKD is most frequently done by calculating the estimated glomerular
Staging CKD Staging ... CKD is most frequently ... function rate (eGFR ... calculating the eGFR ... to remember the eGFR
Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or
Metformin Treatment ... Chronic Kidney Disease ... /dc17-2231 #Metformin ... #CKD3 #CKD4 #Dosing
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... , & an eGFR ≥ 30 ... per 1.73 m2 with metformin ... ADA #KDIGO #eGFR ... #Insulin #metformin
Interpreting Kidney Biomarkers

↑ Creatinine: 
 • AKI, CKD
 • Medications that lead to nephroprotective ↓ in
Creatinine: • AKI, CKD ... nephroprotective ↓ in GFR ... Cystatin C: • AKI, CKD ... hyperthyroidism ↓ eGFR
Renal Failure Prognosis - The eGFR and proteinuria offers a general prognosis as demonstrated in the
Prognosis - The eGFR ... #CKD #EGFR #Proteinuria
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin
Diabetes Type 2 Medication Management and Titration Algorithm
- First line therapy is metformin and comprehensive lifestyle
line therapy is metformin ... Established ASCVD or CKD ... established ASCVD or CKD