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management blood reactions activation cvid dermatology elevation hemolysis hypogammaglobulinemia immunodeficiency immunology intravascular lactate lactic macrophage nonpalpable palpable thromboticthrombocytopenicpurpura transfusion transfusions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... #Causes #differential ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... anemia - Splenomegaly ... deficiency • Liver ... Diagnosis #hematology ... #rheumatology #
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... Purpura Activity ... hallmark for the disease ... Fibrin degradation products ... #Workup #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(eg, systemic juvenile ... with leukopenia, anemia ... , and thrombocytopenia ... • Liver function ... #Hematology #Rheumatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... severe thrombocytopenia ... eruptions, diarrhea, liver ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... severe thrombocytopenia ... eruptions, diarrhea, liver ... #Transfusion #diagnosis ... #management #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
most common causes ... presentations and disease ... of Circulatory System ... - Compartment syndrome ... #Diagnosis #causes
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