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joint pain anemia approach cryoglobulinemia cryoglobulins elevation erythematosus extravascular gap globulin hemolysis hemolytic intravascular lactate lupus management monoarthritis monoarticular myopathy
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... - Drugs (Beta lactam ... #differential # ... diagnosis #hematology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... weeks) Can Be Caused ... Rheumatologic Disease ... #Diagnosis #MSK ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... diseases: - 10% ... #types #classification ... #rheumatology #
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... presentations and disease ... - Compartment syndrome ... Diagnosis #causes ... #typea #typeb #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... rheumatologic diseases ... . hematologic) ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
renal tubular acidosis ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... Arthralgia and Arthritis ... #Rheumatology #
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
#Joint #Pain #MSK ... #rheumatology # ... approach #workup ... #differential # ... diagnosis #arthritis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... (RA, Temporal arteritis ... gastric tumors • Hematology ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... • Nonerosive arthritis ... statins - probably caused ... Myositis #Myopathy #rheumatology ... #differential #
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