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management vasculitis cryofibrinogenemia cryoglobulins dermatology erythematosus gap globulin hodgkins lupus lymphoma mds myelodysplasia myelodysplastic protein proteingap sapho sle syndromes systemic
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... - type II cryoglobulinemia ... #types #classification ... #rheumatology #
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Divided Into Two Types ... Associated Disorders ... Antiphospholipid syndrome ... #rheumatology # ... hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... (e.g. thyroid disease ... • Type-I Interferonopathies ... #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Easy or unusual bruising ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology ... #oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis Framework ... tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... #diagnosis #rheumatology ... #classification
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
chronic inflammatory disorder ... nonerosive inflammatory arthritis ... Rule out other causes ... osteoarticular and skin disease ... #Rheumatology #
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... number of sites of disease ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... gastric tumors • Hematology ... Comment on type ... #diagnosis #hematology
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