11 results
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Creatinine & BUN: • Chronic ... : • Lymphoma ... Myelodisplastic syndrome ... #systemic #generalized ... #dermatology #Differential
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
: • Lymphoma ... Myelodisplastic syndrome ... #Pruritus #secondary ... #systemic #generalized ... #dermatology #Differential
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... cryoglobulinemia syndrome ... 20% Sjögren's syndrome ... #rheumatology #
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
to Systemic Diseases ... discoloration) • Chronic ... • Nephrotic syndrome ... #Secondary #dermatology ... #Differential #
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
processes: • Systemic ... • Negative causes ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... DDX - Other causes ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren syndrome ... • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome ... Erythematosus #Diagnosis #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Mucocutaneous lymph node syndrome ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... #diagnosis #rheumatology ... #classification
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #diagnosis #hematology ... #oncology