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algorithm dermatology generalized pruritus common cvid erythematosus extravascular hemolysis hemolytic hypogammaglobulinemia immunodeficiency immunology intravascular lymphocytic management mds monoclonal myelodysplasia myelodysplastic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Richter’s Syndrome ... , Hodgkin’s lymphoma ... • Sezary syndrome ... #Leukemia #diagnosis ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... develop leukostasis syndrome ... • Tumor lysis syndrome ... lymphoma #Leukemia ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... Myelodysplastic syndrome ... myeloid leukemia ... #Diagnosis #Causes ... #hematology #secondary
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... . lupus, CLL, lymphoma ... . sickle cell disease ... diagnosis #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Creatinine & BUN: • Chronic ... : • Lymphoma ... • Leukemia • ... Myelodisplastic syndrome ... #dermatology #Differential
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
: • Lymphoma ... • Leukemia • ... Myelodisplastic syndrome ... #dermatology #Differential ... #causes
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
' syndrome in the ... Shrinking lung syndrome ... : • Chronic B-cell ... lymphoma and leukemia ... #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... Hyperviscosity syndrome ... (Dermato-neuro syndrome ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Causes • Anemia ... Cell Leukemia ... #diagnosis #hematology ... #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... DDX - Other causes ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
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