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vasculitis common cryoglobulinemia cryoglobulins cvid dermatologic globulin gpa granulomatosis hypogammaglobulinemia immunodeficiency immunology leukemia lupus management myopathy myositis polyangiitis proteingap rash
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... • Goodpasture syndrome ... • Giant cell arteritis ... #dermatology #rash ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... rheumatologic diseases ... pancreatitis, protein-losing ... with Lupus: • Chronic ... #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gap (Total Protein ... changes (POEMS syndrome ... gastric tumors • Hematology ... #differential # ... diagnosis #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... • Nodules • Lymphoid ... DDX - Other causes ... • Burns • Protein-losing ... hypogammaglobulinemia #immunology #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... Type III Often Secondary ... systemic lupus erythematosus ... #types #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... tract, and often causes ... systemic lupus erythematosus ... #diagnosis #rheumatology ... #classification
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... bone marrow and secondary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
ischemia • Skin: Erythematous ... with elevated protein ... Eosinophilia, asthma, chronic ... tract, and often causes ... #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... • Nonerosive arthritis ... statins - probably caused ... Myositis #Myopathy #rheumatology ... #differential #
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