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causes hemolytic leukemia agglutinin chronic cold elevation erythematosus extravascular hemolysis intravascular lactic lupus lymphocytic rheumatology sle systemic typea typeb workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... extramedullary disease ... transformation of the CLL ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Neutropenia, anemia ... or acute leukemia ... #workup #oncology ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
. lupus, CLL, lymphoma ... - Drugs (Beta lactam ... . sickle cell disease ... Extravascular #Causes #differential ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... malignancy (CLL ... malignancies -> CLL ... significance (MGUS), CLL ... #hematology #diagnosis
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
removal from the blood ... presentations and disease ... - Compartment syndrome ... 30mmHg) - Severe anemia ... #typea #typeb #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... • Acute cutaneous ... permanent alopecia Differential ... . hematologic) ... lymphopenia, low PLT • Anemia
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