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differential cardiology endocarditis algorithm amiodarone common cvid fatigue gbs gravis guillain hematology hypogammaglobulinemia immunodeficiency induced infectiousdiseases lung myasthenia myopathy myositis
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Hematologic • Anemia ... Tuberculosis • Epstein-Barr ... Hepatitis • HIV Autoimmune ... Pulmonary Disease Neurologic ... Fatigue Syndrome
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hemolytic anemia ... DDX - Other causes ... infections (Epstein-Barr ... hypogammaglobulinemia #immunology ... #hematology #diagnosis
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... (GBS) Acute autoimmune ... albuminocytologic dissociation ... #Syndrome #diagnosis ... #management #neurology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
myasthenia Diagnosis ... first step in immunologic ... inhibition - Chronic ... Myasthenia #Gravis #diagnosis ... #management #neurology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
regurgitation • Autoimmune ... • Petechiae Immunologic ... due to vascular occlusion ... ↑ ESR, CRP • EKG ... Leukocytosis, anemia
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
hypersensitivity/immunologic ... respiratory distress syndrome ... (e.g., chronic ... Malignancy - Exclusion ... #management #Toxicology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
regurgitation • Autoimmune ... • Petechiae Immunologic ... due to vascular occlusion ... ↑ ESR, CRP • EKG ... Leukocytosis, anemia
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... myopathies Diagnostic ... Aldolase levels • EMG ... phenomenon INCLUSION ... statins - probably caused
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