9 results
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
body mass index; VTE ... #DOAC #VTE #Malignancy ... #Cancer #Algorithm ... Anticoagulation #Management ... #Hematology #Oncology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
algorithm for VTE ... thrombosis in cancer ... #Cancer #Algorithm ... Anticoagulation #Management ... #Hematology #Oncology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... the mainstay of VTE ... heparin (UFH): Inhibits ... the function of ... #Pharmacology #Pathophysiology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... inducers (↑) and inhibitors ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
DPP4 Inhibitors ... has very minimal chance ... check the kidney function ... Renal #Dosing #Pharmacology ... #Management #Diabetes
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Pulmonary Thromboendarterectomy
Chronic Thromboembolic Pulmonary Hypertension
Definition: mean pulmonary-artery pressure > 25mmHg
pulmonary embolism Pathophysiology ... and recurrent VTE ... Phosphodiesterase inhibitor ... variables, WHO functional ... Thromboendarterectomy #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... B-LNH), solid cancers ... Anti-IFN-y and JAK inhibitors ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Systemic Therapy for Hepatocellular Carcinoma - AGA Clinical Practice Guideline

First Line Treatment for HCC with Preserved
Preserved Liver Function ... Systemic #Treatment #Management ... #Hepatology #Gastroenterology ... #oncology #Pharmacology
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity
Anthracyclines cause cardiomyopathy:
 ✖ Reduction in left ventricular ejection fraction
Management of Anthracyclines ... ventricular ejection fraction ... system (RAAS) inhibitor ... Cardiotoxicity #cardiology #oncology ... #pharmacology #