12 results
Treatment of breast cancer: a simplified view
surgical therapy - 5-7 weeks
 - lumpectomy +
 - radiation
Treatment of breast cancer ... mastectomy systemic chemotherapy ... BrighamChiefs #breast #cancer ... #treatment #management ... timeline #simplified #oncology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... inducers (↑) and inhibitors ... #Chemotherapy # ... Oncology #Hematology ... Interactions #Table #Pharmacology
Testicular Cancer - Treatment Related Toxicities

Bleomycin, Cisplatin, Etoposide, lfosfamide
Tinnitus & Hearing Loss
Neurotoxicity
Pulmonary Fibrosis
Hypotension
Nephrotoxicity
Skin Hyperpigmentation
Hemorrhagic Cystitis
Myelosuppression
Peripheral Neuropathy

Ashley
Testicular Cancer ... #Testicular #Cancer ... #chemotherapy # ... toxicology #Toxicities #pharmacology ... #oncology
Checkpoint inhibitors and indications
Anti CTLA-4 antibody:
 • Ipilimumab: Malignant melanoma, Renal cell cancer
Anti-PD-1 antibody:
 • Nivolumab:
Checkpoint inhibitors ... , Gastric cancer ... #Checkpoint #inhibitors ... #indications #oncology ... #pharmacology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
DPP4 Inhibitors ... has very minimal chance ... check the kidney function ... Renal #Dosing #Pharmacology ... #Management #Diabetes
Hyponatremia Differential Diagnosis Algorithm in Cancer
UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Diagnosis Algorithm in Cancer ... deficiency (CTLA4 inhibitors ... adrenalitis; PD-1 inhibitors ... Differential #Diagnosis #Cancer ... algorithm #nephrology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
benefit of immediate chemotherapy ... (Bruton kinase inhibitor ... Venetoclax (BCL2 inhibitor ... Lymphocytic #Leukemia #oncology ... hemeonc #diagnosis #management
Systemic Therapy for Hepatocellular Carcinoma - AGA Clinical Practice Guideline

First Line Treatment for HCC with Preserved
Preserved Liver Function ... Systemic #Treatment #Management ... Gastroenterology #oncology ... #Pharmacology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
specific loss-of-function ... Cytotoxic drugs/Chemotherapy ... Aplastic #Anemia #oncology ... hematology #diagnosis #management
Severe Heart Failure & Cardiogenic Shock - Management Checklist 
Evaluation 
 - EKG & echocardiography
Cardiogenic Shock - Management ... Lactate, Liver function ... (no B-lines on ultrasound ... Treat underlying etiology ... NSAlDs, ACE-inhibitors