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hemophagocytic lymphohistiocytosis rheumatology treatment algorithm antibiotics classification febrile hodgkins lp lymphoma macrophage mas oncology pediatrics stepbystep stratification summary syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... frequently affects infants ... following: • Fever ... #management #treatment ... #hematology
“Step by Step” – the new kid on the block – aims to risk stratify this
” an infant with ... Procalcitonin <0.5 ng/mL ... CRP < 20 mg/L #Diagnosis ... #Management #Pediatrics ... #Peds #Febrile
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... lymphohistiocytosis (HLH ... 5000 to 10,000 ng/mL ... #Syndrome #Diagnosis ... #Management #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma Risk ... • Dyspnea • Fever ... (MCHL) - Lymphocyte ... classification #hematology ... #oncology #management
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