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hemophagocytic lymphohistiocytosis treatment activation algorithm antibiotics calcium classification comparison deposition disease febrile fungal gout hodgkins infections infectiousdiseases lp lymphoma macrophage
“Step by Step” – the new kid on the block – aims to risk stratify this
” an infant with ... Procalcitonin <0.5 ng/mL ... CRP < 20 mg/L #Diagnosis ... #Management #Pediatrics ... #Peds #Febrile
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
frequently affects infants ... following: • Fever ... Ferritin >500 ng/mL ... #management #treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... Ferritin >1000 ng/ml ... sIL-2R >2400 Ul/ml ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
hypersensitivity syndromes • HLH ... 5000 to 10,000 ng/mL ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
locations: Wrist, MCP ... inflammatory response Risk ... 12-24 Hours • Fever ... Gout #Comparison #rheumatology ... #Diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma Risk ... • Dyspnea • Fever ... (MCHL) - Lymphocyte ... classification #hematology ... #oncology #management
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
locations: Wrist, MCP ... culture used to diagnose ... acute neck pain, fever ... Deposition #Disease #Rheumatology ... #diagnosis #management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... MUCORMYCOSIS • Risk ... Encapsulated yeast • At risk ... : • β-D-glucan ... #Management #Infections
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