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Oxygen Hemoglobin Dissociation curve

Curva de disociacion de oxi-hemoglobina
 #Cardiology#CEM
Oxygen Hemoglobin ... disociacion de oxi-hemoglobina
COVID-19 Life Cycle

#COVID19 #LifeCycle #Timeline #Pathophysiology #Diagnosis
Cycle #COVID19 #LifeCycle ... #Timeline #Pathophysiology
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
Oxygen-Hemoglobin ... MatthewHoMD #Oxygen #Hemoglobin ... Dissociation #Curve #pathophysiology
Thalassemias on Hemoglobin Electrophoresis
Beta-Thalassemia:
 • Major
 • Intermediate
 • Trait
Alpha Thalassemia:
 • Trait-1 (α α/ α-)
Thalassemias on Hemoglobin ... or (α α/ --) • Hemoglobin ... H (α -/ --) • Hemoglobin ... Barts(- -/ --) Hemoglobin ... #Thalassemias #Hemoglobin
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
SS disease, Hemoglobin ... SC disease, Hemoglobin ... Hemoglobin C Crystals ... : Hemoglobin C disease ... , Hemoglobin SC
Oxygen Delivery Equation
DO2 = CO x {(1.39 x Hb x sO2) + (PaO2 x 0.03)}
DO2 =
Concentration of Hemoglobin ... oxygen-carrying capacity of hemoglobin ... saturation of effective hemoglobin ... Number of baskets = Hemoglobin ... Delivery #Equation #pathophysiology
The differential diagnosis for an elevated MCHC (mean corpuscular hemoglobin concentration) includes:

Conditions with Abnormal RBCs:
 •
mean corpuscular hemoglobin ... Sickle cells • Hemoglobin ... Hemolysis (i.e., free hemoglobin
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
drugs, Unstable hemoglobin ... Post-splenectomy • Hemoglobin ... H Inclusion: Hemoglobin
Hypoxia and Hypoxemia - Overview
Hypoxia - insufficient oxygen delivered to tissues to meet demands
Hypoxemia - low
saturation of hemoglobin ... loss) or abnormal hemoglobin ... diagnosis #causes #pathophysiology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Haptoglobin, LDH, Urine hemoglobin ... Haptoglobin • ↑ Urine hemoglobin