34 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... Intravascular Hemolysis ... Microangiopathic hemolytic ... • Intrinsic RBC ... G6PD deficiency)
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #Differential #Diagnosis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... immune-complex hemolytic ... malformations #Hemolysis
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... ↑ LDH • Anti-RBC ... Antibody #Autoimmune #Hemolytic ... #rheumatology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
- Differential Diagnosis ... Bleed • Hemolysis ... Microangiopathic Hemolytic ... • Early Iron Deficiency ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... #differential #diagnosis ... #hematology #microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... Immune mediated hemolysis ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Asplenism, Severe hemolytic ... Heinz Bodies: G6PD deficiency ... Sideroblastic anemia, Hemolytic ... : Hemoglobin H disease ... Inclusions #Bodies #diagnosis
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... , Drugs, Liver Disease ... Urobilinogen #Hemolysis ... #hematology