13 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Renal Syndromes ... polyangiitis) - ANCA-negative ... #Renal #Syndrome ... #differential #
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... Renal Syndromes ... EGPA) • Auto-antibodies ... Goodpasture's cause ... #Renal #Syndromes
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... - HIV infection ... neurofibromatosis, vasculitis ... mediastinitis, chronic renal ... #Causes
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
progressing GN • New pulmonary ... and renal abnormalities ... tract, and often causes ... to exclude are infections ... C-ANCA) pattern: antibodies
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... and renal abnormalities ... Vasculitis Differential ... primary condition MEDIUM ... tract, and often causes
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... Clinical Presentation ... for anti-C3d and negative ... hemolytic #anemia #hematology
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
requires special media ... antimicrobials, clinical ... but important causes ... antiphospholipid syndrome ... Diseases Fellows
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... gland) biopsy • Histo ... salivary ducts Clinical ... : • 10%-15% Pulmonary ... Nephrogenic DI Hematologic
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
microscopy and serial ... likely it will be clinically ... Lymphoproliferative Disorders, Infection ... , Interstitial Pulmonary ... #diagnosis #differential
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... Malignancy • Infections ... thrombophlebitis, pulmonary ... causes of secondary ... #hematology