8 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Purpura Anti-GBM antibodies ... With associated pulmonary ... #differential # ... diagnosis #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often causes arthritis ... MEDIUM VESSEL ... to exclude are infections ... ) pattern: antibodies ... #rheumatology #
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of EBV infection ... Immunohistochemical studies (to differentiate ... number of sites of disease ... Lymphoma Treatment ... classification #hematology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
vasculitis (AAV ... life-threatening diseases ... EGPA) • Auto-antibodies ... confirm DAH, r/o infection ... diagnosis #management #treatment
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
serial dilution ... Lymphoproliferative Disorders, Infection ... , Interstitial Pulmonary ... #rheumatology #diagnosis ... #differential
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
gland) biopsy • Histo ... Nephrogenic DI Hematologic ... Malignancy Risk: • Non-Hodgkins ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... primary condition MEDIUM ... often causes arthritis ... #Rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... Malignancy • Infections ... thrombophlebitis, pulmonary ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology