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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilia ... disorders • Diagnosis ... Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
Differential Diagnosis ... of Pulmonary Eosinophilia ... Acute chronic pulmonary ... eosinophilia, Hypereosinophilic ... #Diagnosis #causes
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... /hypereosinophilia ... 1,500 cells/µL • Hypereosinophilia ... #Differential #diagnosis ... #hematology #eosinophilia
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Diagnosis Algorithm ... : • Primary hypereosinophilic ... AI: EGPA, IgG-4 disease ... , Behcet disease ... #Differential #Diagnosis
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... - Differential Diagnosis ... Leukemia - Primary Hypereosinophilic ... #Differential #Diagnosis ... #Causes #hematology
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... Syndrome (HES) - Diagnosis ... with blood eosinophilia ... Alert_Oriented3 #Hypereosinophilia ... #diagnosis #hematology
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
Eosinophils (Eos ... ) and hypereosinophilia ... TerrierBen #Eosinophils ... #hypereosinophilia ... #Differential #Diagnosis
Eosinophilic Pneumonia
When to suspect Eosinophilic Pneumonia? Non-resolving pneumonia + BAL > 25% eosinophils + excluded more
Eosinophilic Pneumonia ... excluded more common diagnoses ... Consolidations AKA "inverse pulmonary ... #Pneumonia #diagnosis ... #pulmonary
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Lung Diseases ... , CV, renal • Hypereosinophilic ... #Lung #Diseases ... #pulmonary #differential ... #diagnosis #comparison
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
No Asthma and Eosinophilia ... Both asthma and eosinophilia ... and/or 10%) - Eosinophilic ... #differential #diagnosis ... #algorithm #rheumatology