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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilia ... disorders • Diagnosis ... Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Definition: An absolute eosinophil ... attributable to eosinophilia ... confirmed tissue eosinophilia ... with blood eosinophilia ... #diagnosis #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Peripheral blood eosinophilia ... specific symptoms • Eosinophilia ... #Differential #diagnosis ... #hematology #eosinophilia
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Mastocytosis - Acute Eosinophilic ... Syndrome - Chronic Eosinophilic ... coyefish379 #Eosinophilia
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Eosinophilia - Differential ... Diagnosis Algorithm ... Primary Eosinophilia ... : • Primary hypereosinophilic ... #Differential #Diagnosis
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
clinically) and asthma/eosinophils ... No Asthma and Eosinophilia ... Both asthma and eosinophilia ... and/or 10%) - Eosinophilic ... #differential #diagnosis
Eosinophilic Pneumonia
When to suspect Eosinophilic Pneumonia? Non-resolving pneumonia + BAL > 25% eosinophils + excluded more
Eosinophilic Pneumonia ... When to suspect Eosinophilic ... excluded more common diagnoses ... Acute Eosinophilic ... #Pneumonia #diagnosis
Eosinophilic meningitis
#eosinophilicmeningitis #eosmeningitis #angiostrongylus #baylisascaris #gnathostoma #raccoon #snail

By Dr. Sara Dong @swinndong via Febrile [febrilepodcast.com
Eosinophilic meningitis ... Differential #Ddx #Diagnosis ... #eosinophilia ... #eosinophil #fever
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
of Pulmonary Eosinophilia ... Tropical pulmonary eosinophilia ... sting Others: • Eosinophilic ... chronic pulmonary eosinophilia ... , Hypereosinophilic
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... Diseases • Acute Eosinophilic ... #differential #diagnosis ... #comparison #table ... #eosinophilia