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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
disorders • Diagnosis ... Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis ... #management #algorithm
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
attributable to eosinophilia ... confirmed tissue eosinophilia ... with blood eosinophilia ... #diagnosis #hematology ... #eosinophils
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Peripheral blood eosinophilia ... specific symptoms • Eosinophilia ... #Differential #diagnosis ... #hematology #eosinophilia
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Mastocytosis - Acute Eosinophilic ... Syndrome - Chronic Eosinophilic ... coyefish379 #Eosinophilia
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Eosinophilia - Differential ... Diagnosis Algorithm ... Primary Eosinophilia ... : • Primary hypereosinophilic ... #Differential #Diagnosis
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
clinically) and asthma/eosinophils ... No Asthma and Eosinophilia ... Both asthma and eosinophilia ... and/or 10%) - Eosinophilic ... #differential #diagnosis
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
of Pulmonary Eosinophilia ... Tropical pulmonary eosinophilia ... sting Others: • Eosinophilic ... chronic pulmonary eosinophilia ... , Hypereosinophilic
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... Diseases • Acute Eosinophilic ... #differential #diagnosis ... #comparison #table ... #eosinophilia
ANCA Vasculitis - GPA, MPA, Eosinophilic GPA

doi:10.1038/s41572-020-0204-y

#ANCA #Vasculitis #GPA #MPA #Eosinophilic #rheumatology #diagnosis #comparison #table
Vasculitis - GPA, MPA, Eosinophilic ... Vasculitis #GPA #MPA #Eosinophilic ... #rheumatology # ... diagnosis #comparison ... #table
Categories of disease to consider for eosinophilic meningitis:
-Multicellular parasites (worms and flukes)
-Fungal: Cocci
-Atypical bacterial/mycobacterial: TB, syphilis,
to consider for eosinophilic ... Hypereosinophilic ... -Medications #Diagnosis ... #Eosinophilic # ... Eosinophilia #Meningitis