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Exposure Related ILD • Hypersensitivity pneumonitis • Pneumoconioses • Radiation pneumonitis • Medication-induced ILD Andrew Sanchez
Exposure Related ILD ... • Hypersensitivity ... Medication-induced ILD ... Exposure #Related #ILD
Interstitial Lung Diseases (ILD) Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): • Hypersensitivity pneumonitis, Farmer's lung, Bird
Lung Diseases (ILD ... Exposure-Related ILD ... alveolitis): • Hypersensitivity ... ILD caused by inhalation ... Methotrexate ILD
ILD of Known Cause - Differential Diagnosis Exposure: • Occupational: Asbestosis, Silicosis, Hypersensitivity, Pneumonitis • Treatment Related:
ILD of Known Cause ... Asbestosis, Silicosis, Hypersensitivity ... BrighamChiefs #ILD
Approach to the diagnosis of chronic hypersensitivity pneumonitis. *Consider additional test: bronchoscopy with bronchoalveolar lavage, transbronchial
diagnosis of chronic hypersensitivity ... cHP = chronic hypersensitivity ... #hypersensitivity ... algorithm #HP #ILD
Lung Nodules - Differential Diagnosis by Distribution • Centrilobular: Hypersensitivity Pneumonitis, RB-ILD, Pneumoconiosis, Infectious Bronchiolitis, Vasculitis,
Centrilobular: Hypersensitivity ... Pneumonitis, RB-ILD
Types of hypersensitivity reactions Type I - lgE-Mediated, Within I Hour (Anaphylaxis) Type II - IgG or IgM
Types of hypersensitivity ... Anemia) Type Ill ... happypillsrx/ #hypersensitivity
Upper lung zone preference is seen in: - Inhaled particles: pneumoconiosis (silica or coal) - Smoking related diseases
bronchiolitis (RB-ILD ... histiocytosis - Hypersensitivity
Nodular pattern 1. Hypersensitivity pneumonitis: ill defined centrilobular nodules. 2. Miliary TB: random nodules 3. Sarcoidosis: nodules with perilymphatic
Hypersensitivity ... pneumonitis: ill ... Hypersensitivity
On the left some diseases with a nodular pattern. 1. Hypersensitivity pneumonitis: ill defined centrilobular nodules. 2. Miliary
Hypersensitivity ... pneumonitis: ill ... Hypersensitivity ... bronchiolitis: ill
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Hypersensitivity ... Summary Type I Hypersensitivity ... Disease Type III Hypersensitivity ... sickness Type IV Hypersensitivity ... poison ivy) #Hypersensitivity
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