17 results
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... erythematosus (SLE ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... Associated with skin ... /systemic sclerosis ... Summary #diagnosis #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... context of other symptoms ... Kumfer @AnnKumfer #Antinuclear ... ANA #patterns #rheumatology ... #diagnosis #differential
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Sjögrens (15%) Skin ... Thrombocytopenia #Lupus #SLE ... #signs #symptoms ... #diagnosis #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... drug-dependent) • Immunologic ... constitutional symptoms ... months to years) Systemic ... comparison #table #rheumatology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders - Differential ... arthritis - with the skin ... Erythematosus (SLE ... should have other symptoms ... Disorders #msk #Differential
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Lupusreference #SLE ... #Systemic #Lupus ... autoantibodies #signs #symptoms ... #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Neurologic system ... Genitourinary system ... Scleroderma Thickened skin ... #joint #pain #differential ... #diagnosis #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome Systemic ... Behcet disease) Differential ... Oral aphthae : SLE ... • Arthritis: SLE ... #rheumatology #
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Induced Lupus: • Symptoms