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Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... thiazide-sensitive sodium-chloride ... H+ secretion → Hypokalemia ... #Pathophysiology ... #nephrology #diagnosis
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
ON (UNa < 30): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... Primary polydipsia, Low ... Hyponatremia #Algorithm #diagnosis ... #sodium #nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
Present (Uosm ≥100): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... #differential #diagnosis ... #table #sodium ... #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... alkalosis • Normal or low ... #diagnosis #nephrology ... #management #pathophysiology
Hyponatremia - Differential Algorithm
Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP
Hypotonic Hyponatremia: 
 • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
Hyponatremia: • Hypovolemia ... Cirrhosis, Nephrotic Syndrome ... Differential #Algorithm #diagnosis ... #causes #nephrology ... #sodium #low
Bulimia Nervosa: Complications
GASTROINTESTINAL
 • Dehydration & inability to digest food -> Constipation
 • Recurrent vomiting exposes
• Boerhaave syndrome ... hormonal imbalances (low ... > Amenorrhea & Infertility ... Complications #pathophysiology ... #diagnosis #signs
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
mental status and low ... patient causing hypovolemia ... acute coronary syndrome ... algorithm #management #cardiology ... #treatment #table
Causes of ST Segment Elevation - Differential Diagnosis Framework

STEMI:
 • Upsloping convex STE: "Pardee's sign" +
- Differential Diagnosis ... Disorders: • Hyperkalemia ... Tower sign) and low-amplitude ... dissection • Sodium-channel ... #cardiology #ecg