10 results
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
chest (in a V-sign ... Inverse Gottron’s sign ... severity of the disease ... #rheumatology # ... dermatology #diagnosis
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung disease ... Granulomatous disease ... • Liver diseases ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
: • Most common ... Orange or Hep C Clinical ... Physical Exam/Signs ... cells can indicate disease ... workup #oncology #hematology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... symptoms/signs ... disease; AST, aspartate ... disease; T2DM, ... #Algorithm #Hepatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... age, however the disease ... : HLH signs and ... #hematology
Nail Pathologies - Findings in or Near Nails

Paronychia 

A superficial infection of the proximal and lateral
congenital heart disease ... interstitial lung disease ... Seen in liver disease ... #Diagnosis #Clinical ... #Signs #PhysicalExam
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
• Heavy chain disease ... plasmacytoma • Castleman disease ... disease: Cirrhosis ... gastric tumors • Hematology ... #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Systemic rheumatic diseases ... atherosclerotic disease ... most important diseases ... purpura: Strong sign ... #Rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... (NSHL) - (most common ... number of sites of disease ... classification #hematology ... #oncology #management
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... shoulders (in a shawl sign ... Muscle atrophy may cause ... had more severe disease ... #management #rheumatology