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differential hemophagocytic hlh lymphohistiocytosis behcet chronic leukemia lymphocytic ms myelitis polychondritis relapsing sclerosis sjogrens symptoms transverse vasculitis workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... #workup #oncology ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... : HLH signs and ... #management #treatment ... #hematology
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
- Summary Multiple ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... Signs and symptoms ... #management #neurology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... : SLE+++, Adult-onset ... Still disease, ... #management #treatment ... #summary #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
inflammation of multiple ... skin injury) • Neurologic ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... , mononeuritis multiplex ... #Rheumatology # ... Diagnosis #Management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... purpura: Strong sign ... CRP GCA (Giant Cell ... affects the skin, neurologic ... #Rheumatology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... Transverse Myelitis - Clinical ... • Bilateral signs ... Transverse Myelitis Treatment ... #management #neurology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cases such as: • SLE ... , MDS & Multiple ... affected tissue Treatment ... Polychondritis #rheumatology ... #diagnosis #management
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