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diagnosis fungal differential infectiousdiseases management neurology betadglucan galactomannan aids biomarkers comparison encephalitis falsepositives hiv ia invasive laboratory meningitis mycoses myelitis
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
HIV/AIDS, CGD) Clinical ... Rhinosinusitis, CNS ... Diagnosis and Testing ... Galactomannan sensitivity ... and low specificity
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
CNS Infection in ... should be based on clinical ... of serum CrAg testing ... comparable to CSF testing ... Others CNS Infections
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
& Specificity: ... invasive fungal infection ... cut-offs defined in clinical ... surfaces - Infections ... Frozen ice-pops (in setting
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... Sensitivity Specificity ... 96% • Higher specificity ... surfaces, Albumin, Infections ... >90% (In most clinical
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... virus • CMV • EBV ... • Common clinical ... and specificity ... and specificity
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... that results in CNS ... Transverse Myelitis - Clinical ... Hyperreflexia develops later ... Brucellosis - Dengue, EBV
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
antigen assay has a sensitivity ... and specificity ... Urinary antigen testing ... ASPERGILLOSIS • Aspergillus ... Aspergillosis Pathophysiology
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